Opioid overdoses claim the lives of six people a day in Massachusetts. Proactively addressing the epidemic via resilience initiatives is a step towards curtailing abuse and deaths. We plan to expand and scale evidence-based efforts to deploy a strategy against opioids, substance abuse, and rising overdose rates. The goal is to prioritize prevention, reduce risk factors, and promote resilient approaches for impacted groups. Study investigators’ strong connections with public-health practitioners and community engagement centers enable the proposed community-based prevention and intervention approaches.