A progressive age related deterioration of the body compromises tissues and organs thereby causing irreversible damage and loss of functionality. Diseases of immobility are the most common cause of trauma to the physical and emotional well-being of older adults. Strategies to recuperate from joint injury or gradual musculoskeletal degeneration, can improve mobility, reduce depression, and promote greater independence in our elderly population. We propose to increase resilience in the aging population by developing novel ways of treating osteoarthritis (OA), the most common musculoskeletal disease and the leading cause of immobility. We will approach this challenge with a combination of scientific research and lifestyle management strategies. The project will examine fundamental questions such as why joint cells age, how diet and exercise influence joint aging, and what are the most effective and efficient therapies for delaying and treating osteoarthritis.